I have to agree "Jesus Built my Hot Rod" is one of the best driving songs ever!
Several years a friend and I took a road trip to an Aveda spa. After 3 days of being massaged, perfumed, lulled with harp music and no spoken word above a whisper, we jumped into the Vette, dropped the top, cranked up Ministry and peeled out of their scented parking lot in a cloud of dust and exhaust. But do watch your speed, I have caught myself doing about 95 on the beltline when that one is on!
I also second Roadrunner.
You Can't Catch Me ~Rolling Stones
Start Me Up " "
Built for Speed or anything by the Stray Cats
Girl Can't Help It ~Little Richard
Little Red Corvette (natch) ~Prince
Peter Gunn Theme ~Art of Noise
Key to your Ferrari ~Thomas Dolby
Girls just want to have Fun ~Cyndi Lauper
Freeway of Love ~Aretha Franklin
Miami Vice Theme, extended remix ~Jann Hammer
Wild Wild Life Talking Heads
There's a Barbarian in the back of my Car ~Voice of the Beehive
Blitzkrieg Bop ~The Ramones
Route 66 ~Brian Setzer Orchestra
King of the Road ~Roger Miller
I Want Candy ~Bow Wow Wow
And of course, with your destination in mind:
City of New Orleans Arlo Guthrie
I have about 3 hundred more.......